Abrams’ Clinical Drug Therapy: Rationales for Nursing Practice 12th Edition PDF

SECTION 1
THE CONCEPTUAL FRAMEWORK OF
PHARMACOLOGY
1 The Foundation of Pharmacology: Quality and Safety
Introduction
Drug Sources
Drug Classifications and Prototypes
Drug Names
Drug Marketing
Pharmacoeconomics
Pharmacogenomics
Access to Drugs
Drug Approval Processes: Food and Drug Administration
Safety in Drug Administration
Sources of Drug Information
Strategies for Studying Pharmacology
2 Basic Concepts and Processes
Introduction
Cellular Physiology
Drug Transport Through Cell Membranes
Pharmacokinetics
Pharmacodynamics
Variables That Affect Drug Actions
Adverse Effects of Drugs
Toxicology: Drug Overdose
3 Medication Administration and the Nursing Process of Drug
Therapy
Introduction
General Principles of Accurate Drug Administration
Legal Responsibilities
Medication Errors and Their Prevention
Medication Orders
Drug Preparations and Dosage Forms
Calculating Drug Dosages
Routes of Administration
Nursing Process in Drug Therapy
Integrating Evidence-Based Practice With the Nursing Process
Herbal and Dietary Supplements
SECTION 2
DRUG THERAPY THROUGHOUT THE LIFESPAN
4 Pharmacology and the Care of Infants and Pediatric Patients
Introduction
Drug Safety in Pediatrics
Pharmacotherapy in Pediatrics
Medication Administration in Pediatrics
5 Pharmacology and the Care of Adults and Geriatric Patients
Introduction
Pharmacodynamics in Older Adults
Pharmacokinetics in Older Adults
Medication Adherence and Aging
6 Pharmacology and the Care of Pregnant or Lactating Women
Introduction
Drug Therapy for Infertility
Drugs Used in Pregnancy
Fetal Therapeutics
Maternal Therapeutics
Drugs That Alter Uterine Motility: Tocolytics
Drugs Used During Labor and Delivery at Term
Lactation
7 Pharmacology and Women’s Health
Introduction
Overview of Reproduction in Women
Common Reproductive Health Problems in Women
Estrogens
Progestins
Estrogen–Progestin Combinations
8 Pharmacology and Men’s Health
Introduction
Overview of Reproductive Health Problems in Men
Androgens and Anabolic Steroids
Phosphodiesterase Type 5 Inhibitors
Adjuvant Medications Used to Treat Erectile Dysfunction
Drugs for Benign Prostatic Hypertrophy
5-Alpha Reductase Inhibitors
Alpha1-Adrenergic Blockers
SECTION 3
DRUGS AFFECTING THE HEMATOPOIETIC
AND IMMUNE SYSTEMS
9 Drug Therapy for Coagulation Disorders
Introduction
Overview of Coagulation Disorders
Anticoagulant Drugs
Antiplatelet Drugs
Thrombolytic Drugs
Drugs Used to Control Bleeding
10 Drug Therapy for Dyslipidemia
Introduction
Overview of Dyslipidemia
HMG-CoA Reductase Inhibitors
Bile Acid Sequestrants
Fibrates
Cholesterol Absorption Inhibitor
PCSK9 Inhibitors
Miscellaneous Dyslipidemic Agent
Combination Therapy Used to Treat Dyslipidemia
11 Drug Therapy for Hematopoietic Disorders
Introduction
Overview of Hematopoiesis and Immune Function
Erythropoiesis-Stimulating Agents
Granulocyte Colony-Stimulating Factors
Interferons
Adjuvant Medications Used to Stimulate the Immune System:
Interleukins
12 Drug Therapy: Immunizations
Introduction
Overview of Immunization
Individual Immunizing Agents
Keeping Up-to-Date With Immunization Recommendations
13 Drug Therapy to Decrease Immunity
Introduction
Overview of Altered Immune Function
Cytotoxic Immunosuppressive Agents
Conventional Antirejection Agents
Janus Associated Kinase Inhibitor
Adjuvant Medications Used to Suppress Immune Function
14 Drug Therapy for the Treatment of Cancer
Introduction
Overview of Cancer
Cytotoxic Antineoplastic Drugs Used to Treat Cancer
Adjuvant Medications Used to Treat Cancer
SECTION 4
DRUGS AFFECTING INFLAMMATION AND
INFECTION
15 Inflammation, Infection, and the Use of Antimicrobial Agents
Introduction
Overview of Inflammation
Overview of Microorganisms
16 Drug Therapy to Decrease Pain, Fever, and Inflammation
Introduction
Overview of Pain, Fever, and Inflammation
Specific Conditions
Gout
Salicylates
Nonnarcotic Analgesic Antipyretic: Acetaminophen
Nonsteroidal Anti-Inflammatory Drugs
Propionic Acid Derivatives
Oxicam Derivatives
Acetic Acid Derivatives
Selective COX-2 Inhibitor: Celecoxib
Antigout Medication
Uricosuric Agents
17 Drug Therapy With Corticosteroids
Introduction
Physiology of Endogenous Corticosteroids
Pathophysiology of Adrenal Cortex Disorders
Drug Therapy with Exogenous Corticosteroids
18 Drug Therapy With Beta-Lactam Antibacterial Agents
Introduction
Penicillins
Cephalosporins
Carbapenems
Monobactams
19 Drug Therapy With Aminoglycosides and Fluoroquinolones
Introduction
Aminoglycosides
Fluoroquinolones
20 Drug Therapy With Tetracyclines, Sulfonamides, and Urinary
Antiseptics
Introduction
Tetracyclines
Sulfonamides
Adjuvant Medications Used to Treat Urinary Tract Infections:
Urinary Antiseptics
21 Drug Therapy With Macrolides and Miscellaneous Antiinfective
Agents
Introduction
Macrolides
Miscellaneous Anti-infective Agents
22 Drug Therapy for Tuberculosis and Mycobacterium Avium
Complex Disease
Introduction
Overview of Tuberculosis and Mycobacterium Avium Complex
Disease
Isoniazid
Rifamycins
Adjuvant First-Line Antitubercular Drugs
First-Line Drug Combinations Used to Treat Tuberculosis
Second-Line Drugs Used to Treat Tuberculosis
Drugs Used to Treat Mycobacterium Avium Complex Disease
Special Strategies to Increase Adherence to Antitubercular Drug
Regimens
23 Drug Therapy for Viral Infections
Introduction
Overview of Viruses and Viral Infections
Drugs for Herpesvirus Infections
Drugs for Respiratory Syncytial Virus
Monoclonal Antibody for Respiratory Syncytial Virus
Drugs for Hepatitis B: Nucleoside Analogs
Drugs for Hepatitis C: Polymerase Inhibitors
Drugs for Human Immunodeficiency Virus (Antiretroviral Drugs)
Protease Inhibitors
Cytochrome P-450 Inhibitor
Combination Medication for HIV-1: Integrase Inhibitor, Reverse
Transcriptase Inhibitor, Nucleoside, Reverse Transcriptase
Inhibitor, Nucleotide
24 Drug Therapy for Fungal Infections
Introduction
Overview of Fungal Infections
Polyenes
Azoles
Echinocandins
Miscellaneous Antifungal Agents for Superficial Mycoses
Pyrimidine Analog
25 Drug Therapy for Parasitic Infections
Introduction
Overview of Parasitic Infections
Amebicides
Antimalarials
Anthelmintics
Scabicides and Pediculicides
SECTION 5
DRUGS AFFECTING THE CARDIOVASCULAR
SYSTEM
26 Drug Therapy for Hypertension
Introduction
Overview of Hypertension
Angiotensin-Converting Enzyme Inhibitors
Angiotensin II Receptor Blockers
Calcium Channel Blockers
Adjuvant Medications Used to Treat Hypertension
27 Drug Therapy for Dysrhythmias
Introduction
Overview of Dysrhythmias
Class I Sodium Channel Blockers
Class IA
Class IB
Class IC
Class II Beta-Adrenergic Blockers
Class III Potassium Channel Blockers
Class IV Calcium Channel Blockers
Unclassified Antidysrhythmic Drugs
Drug Therapy in Emergency Resuscitation of Adults
Magnesium Sulfate
28 Drug Therapy for Coronary Heart Disease
Introduction
Overview of Coronary Artery Disease
Organic Nitrates
Beta-Adrenergic Blockers
Calcium Channel Blockers
Adjuvant Medications
29 Drug Therapy for Shock and Hypotension
Introduction
Overview of Acute Hypotension and Shock
Treatment of Hypotension and Shock
Adrenergic Drugs
30 Drug Therapy for Heart Failure
Introduction
Overview of Heart Failure
Cardiac Glycosides
Phosphodiesterase Inhibitors (Cardiotonic–Inotropic Agents)
Angiotensin Receptor–Neprilysin Inhibitors
Sinoatrial Node Modulators
Adjuvant Medications Used to Treat Heart Failure
SECTION 6
DRUGS AFFECTING THE RESPIRATORY
SYSTEM
31 Drug Therapy for Nasal Congestion and Cough
Introduction
Overview of Nasal Congestion and Other Respiratory Symptoms
Nasal Decongestants
Antitussives
Expectorants
Mucolytics
Herbal Remedies and Other Preparations
Combination Products
32 Drug Therapy to Decrease Histamine Effects and Allergic
Response
Introduction
Overview of Histamine Release and the Allergic Response
First-Generation H1 Receptor Antagonists
Second-Generation H1 Receptor Antagonists
Third-Generation H1 Receptor Antagonists
33 Drug Therapy for Asthma, Airway Inflammation, and
Bronchoconstriction
Introduction
Overview of Asthma
Adrenergics
Anticholinergics
Xanthines
Corticosteroids
Leukotriene Modifiers
Immunosuppressant Monoclonal Antibodies
Adjuvant Medications Used to Treat Asthma
SECTION 7
DRUGS AFFECTING THE RENAL AND
DIGESTIVE SYSTEMS
34 Drug Therapy for Fluid Volume Excess
Introduction
Renal Physiology
Overview of Conditions Requiring Diuretic Agents
Loop Diuretics
Thiazide Diuretics
Potassium-Sparing Diuretics
Adjuvant Medications Used to Treat Fluid Volume Excess
35 Nutritional Support Products, Vitamins, and Mineral
Supplements
Introduction
Overview of Altered Nutritional States
Fat-Soluble Vitamins
Water-Soluble Vitamins
Minerals
Nutritional Products
36 Drug Therapy for Weight Management
Introduction
Overview of Weight Management
Noradrenergic Sympathomimetic Anorexiants
Lipase Inhibitors
Other Drugs Used for Weight Management
Herbal and Dietary Supplements Used for Weight Management
37 Drug Therapy for Peptic Ulcer Disease and Hyperacidity
Introduction
Overview of Peptic Ulcer Disease and Gastroesophageal Reflux
Disease
Antacids
Histamine2 Receptor Antagonists
Proton Pump Inhibitors
Adjuvant Medications Used to Treat Peptic Ulcer Disease and
Gastroesophageal Reflux Disease
38 Drug Therapy for Nausea and Vomiting
Introduction
Overview of Nausea and Vomiting
Phenothiazines
Antihistamines
5-Hydroxytryptamine3 (5-HT3) or Serotonin Receptor
Antagonists
Substance P/Neurokinin 1 Antagonists
Miscellaneous Antiemetics
Nonpharmacologic Management
39 Drug Therapy for Constipation and Elimination Problems
Introduction
Overview of Constipation
Laxatives
Cathartics
Miscellaneous Agents for Constipation
40 Drug Therapy for Diarrhea
Introduction
Overview of Diarrhea
Opiate-Related Antidiarrheal Agents
Adjuvant Medications Used to Treat Diarrhea
SECTION 8
DRUGS AFFECTING THE ENDOCRINE SYSTEM
41 Drug Therapy for Diabetes Mellitus
Introduction
Overview of Diabetes
Insulins
Sulfonylureas
Biguanide
Alpha-Glucosidase Inhibitors
Thiazolidinediones
Meglitinides
Dipeptidyl Peptidase 4 Inhibitors
Amylin Analogs
Glucagon-Like Peptide-1 Receptor Agonists (Incretin Mimetics)
Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors
Combination Drug Therapy for Type 2 Diabetes
Adjuvant Medications Used to Treat Diabetes
42 Drug Therapy for Hyperthyroidism and Hypothyroidism
Introduction
Overview of the Thyroid Gland
Antithyroid Drugs
Adjuvant Medication Used to Treat Hyperthyroidism
Thyroid Drugs
43 Drug Therapy for Pituitary and Hypothalamic Dysfunction
Introduction
Overview of Pituitary and Hypothalamic Dysfunction
Anterior Pituitary Hormone Drugs for Growth Deficiency in
Children
Posterior Pituitary Hormone Drugs for Diabetes Insipidus
Hypothalamic Hormone Drugs
44 Drug Therapy to Regulate Calcium and Bone Metabolism
Introduction
Overview of Calcium and Bone Metabolism
Calcium Preparations
Vitamin D
Bisphosphonates
Other Medications Used to Treat Bone Disorders and
Hypercalcemia
45 Drug Therapy for Adrenal Cortex Disorders
Introduction
Overview of Addison’s Disease
Overview of Cushing’s Disease
Drugs Used to Treat Addison’s Disease
Drugs Used to Treat Cushing’s Disease
Glucocorticoid Receptor Antagonists
SECTION 9
DRUGS AFFECTING THE AUTONOMIC AND
CENTRAL NERVOUS SYSTEM
46 Physiology of the Autonomic and Central Nervous Systems
and Indications for the Use of Drug Therapy
Introduction
Structure and Function of the Autonomic Nervous System
Characteristics of Autonomic Drugs
47 Drug Therapy for Myasthenia Gravis, Alzheimer’s Disease,
and Other Conditions Treated with Cholinergic Agents
Introduction
Overview of Myasthenia Gravis
Acetylcholinesterase Inhibitors (Indirect-Acting Cholinergics)
Immunosuppressive Therapy for Myasthenia Gravis
Overview of Alzheimer’s Disease
Cholinesterase Inhibitors: Reversible Indirect-Acting
Cholinergics
N-Methyl-D-Aspartate Receptor Antagonist
Cholinesterase Inhibitor–N-Methyl-D-Aspartate Receptor
Antagonist
Overview of Urinary Retention
Cholinergic Agonist
Irreversible Anticholinesterase Toxicity
48 Drug Therapy for Parkinson’s Disease, Urinary Spasticity,
and Disorders Requiring Anticholinergic Drug Therapy
Introduction
Overview of Parkinson’s Disease
Dopamine Receptor Agonists
Catechol-O-Methyltransferase Inhibitors
Catechol-O-Methyltransferase Inhibitor and Decarboxylase
Inhibitor/Dopamine Precursor
Overview of Anticholinergic Drugs
Belladonna Alkaloid and Derivatives
Centrally Acting Anticholinergics
Gastrointestinal Anticholinergics (Antisecretory/Antispasmodic)
Urinary Antispasmodics
49 Drug Therapy With Opioids
Introduction
Overview of Impact of the Opioid Epidemic
Overview of Pain
Opioid Agonists
Opioid Agonists/Antagonists
Opioid Antagonists
50 Drug Therapy With Local Anesthetics
Introduction
Overview of Local Anesthesia
Amides
Esters
51 Drug Therapy With General Anesthetics
Introduction
Overview of General Anesthesia
Inhalation Anesthetics
Intravenous General Anesthetics
Neuromuscular Blocking Agents
Adjuvant Medications Used in General Anesthesia
52 Drug Therapy for Migraine and Other Headaches
Introduction
Overview of Headaches
Nonsteroidal Anti-Inflammatory Agents
Acetaminophen, Aspirin, and Caffeine
Ergot Alkaloids
Triptans
Estrogen
Preventive Therapy for Migraine Headaches
Adjuvant Medications for Migraine Headaches
53 Drug Therapy for Seizure Disorders and Skeletal Muscle
Disorders
Introduction
Overview of Epilepsy
Drugs Used to Treat Seizure Disorders
Other Antiepileptic Drugs
Overview of Spinal Cord Injury
Drugs Used to Treat Muscle Spasms and Spasticity
54 Drug Therapy for Anxiety and Insomnia
Introduction
Overview of Anxiety
Overview of Sleep and Insomnia
Benzodiazepines
Nonbenzodiazepine Sedative–Hypnotic Agents
55 Drug Therapy for Depression and Mood Stabilization
Introduction
Overview of Depression
Overview of Bipolar Disorder
Tricyclic Antidepressants
Selective Serotonin Reuptake Inhibitors
Serotonin–Norepinephrine Reuptake Inhibitors
Monoamine Oxidase Inhibitors
Atypical Antidepressants
Mood-Stabilizing Agents: Drugs Used to Treat Bipolar Disorder
Other Medications Used to Treat Bipolar Disorder
56 Drug Therapy for Psychotic Disorders
Introduction
Overview of Psychosis
First-Generation Antipsychotics
First-Generation Nonphenothiazines
Second-Generation “Atypical” Antipsychotics
57 Drug Therapy for Attention Deficit Hyperactivity Disorder
and Narcolepsy
Introduction
Overview of Attention Deficit Hyperactivity Disorder
Overview of Narcolepsy
Stimulants
Amphetamines
Amphetamine-Related Drugs
Other Medications Used to Treat Attention Deficit Hyperactivity
Disorder and Narcolepsy
58 Drug Therapy for Substance Use Disorders
Introduction
Overview of Substance Use
Central Nervous System Depressant Use: Drug Therapy
Benzodiazepines for Treatment of Alcohol Withdrawal
Enzyme Inhibitors for Maintenance of Alcohol Sobriety
Drugs Used to Reduce Cravings in Alcohol Use
Opioid Agonists and Antagonists for Treatment of Opioid Abuse
Central Nervous System Stimulant Abuse: Drug Therapy
Psychoactive Substance Use: Drug Therapy
SECTION 10
DRUGS AFFECTING THE EYE, EAR, AND SKIN
59 Drug Therapy for Disorders of the Eye
Introduction
Basic Structure and Function of the Eye
Overview of Disorders of the Eye
Drug Therapy for the Diagnosis and Treatment of Ocular
Disorders
Drug Therapy for the Treatment of Glaucoma
Alpha2-Adrenergic Agonists and Carbonic Anhydrase Inhibitors
Drug Therapy for Ocular Infections and Inflammation
60 Drug Therapy for Disorders of the Ear
Introduction
Overview of Disorders of the Ear
Anti-infective, Antiseptic, Glucocorticoid, and Acidifying Agents
Fluoroquinolone: Ciprofloxacin
Penicillin: Amoxicillin
Adjuvant Medications to Treat Pain and Fever Related to
Infections of the Ear
61 Drug Therapy for Disorders of the Skin
Introduction
Disorders of the Skin
Drug Therapy
Retinoids
Index
Abrams’ Clinical Drug Therapy: Rationales for Nursing Practice 12th Edition PDF Ebook

Geralyn Frandsen, EdD, RN
Assistant Director of Nursing
Professor of Nursing
Catherine McAuley School of Nursing
Maryville University
St. Louis, Missouri
Sandra Smith Pennington, PhD, RN
Chief of Staff, Office of the President
Rocky Mountain University of Health Professions
Provo, Utah
Professor Emeritus
Department of Nursing
Berea College
Berea, Kentucky