Foreword xxv
List of Contributors xxvii
Section I Epilepsy: Epidemiology, Diagnostic Evaluation and Co-Morbidities 1
1 Introduction and Epidemiology 3
Joseph I. Sirven and Gregory D. Cascino
2 Classification of Seizures and the Epilepsies 11
Elaine C. Wirrell
3 Etiology and Pathology of Epilepsy 23
Katherine C. Nickels and Katherine Noe
4 Genetics of Epilepsy 37
Anthony L. Fine, Lily C. Wong-Kisiel and Raj D. Sheth
5 Burden of Epilepsy 63
J. Layne Moore, Amy Z. Crepeau and Gregory D. Cascino
6 EEG and Epilepsy 77
Anteneh M. Feyissa, Gregory A. Worrell and Terrence D. Lagerlund
7 Neuroimaging in Epilepsy 99
Benjamin H. Brinkmann, Elson L. So, Robert E. Watson and Amy L. Kotsenas
8 The Evaluation of Nonepileptic Paroxysmal Events 117
Sara Dawit and Joseph F. Drazkowski
9 Sleep, Sleep Disorders, and Epilepsy 133
Diego Z. Carvalho, J. Layne Moore and Erik K. St. Louis
Epilepsy Journey: Identification of a Genetic Etiology for Epilepsy 147
Anthony L. Fine, Lily C. Wong-Kisiel and Raj D. Sheth
Epilepsy Journey 2: Evaluation of Spells in Adults 153
David B. Burkholder
Epilepsy Journey 3: The Pediatric Patient with Spells: Recommendations for Evaluation 157
Katherine C. Nickels and Elaine C. Wirrell
Epilepsy Journey 4: Transitioning from Pediatric to Adult Epilepsy Clinic 165
Gregory D. Cascino, Katherine C. Nickels and Elaine C. Wirrell
Section II Epilepsy: Treatment of Epilepsy: Non-Surgical Therapy 169
10 First Seizure 171
Scott Spritzer and Omar Danoun
11 Antiseizure Medication Therapy 179
Kiran M. Kanth, Sarah Clark and Jeffrey W. Britton
12 Epilepsy in Women 217
Katherine Noe
13 Treating Children with Epilepsy: Antiepileptic Medications (AEDs) 229
Raj D. Sheth
14 Dietary Therapy in Epilepsy 239
Katherine C. Nickels and Elaine C. Wirrell
15 Autoimmune Epilepsy Disorders 249
Jeffrey W. Britton, Eoin P. Flanagan, Andrew McKeon and Sean J. Pittock
16 Discontinuation of Antiseizure Medication 275
Jamal F. Khattak and Jeffrey W. Britton
17 Investigational Therapy and Drug Approval Process within the US and Cannabidiol 287
Gregory Sprout, Joseph I. Sirven and Gregory D. Cascino
18 Devices to Monitor and Track Your Epilepsy 301
Nicholas M. Gregg and Amy Z. Crepeau
Epilepsy Journey 5: Seizure Emergencies (Include status Epilepticus, Fires, Norse, Seizure First Aid, and Seizure Clusters) 313
Anteneh M. Feyissa, Matthew T. Hoerth and Eric T. Payne
Epilepsy Journey 6: The First seizure — How to Evaluate: Pediatric 315
Korwyn Williams
Epilepsy Journey 7: The First Seizure — How to Evaluate: Adult 317
Paul M. Magtibay and Joseph I. Sirven
Epilepsy Journey 8: Treating Epilepsy Second Seizure and beyond: How to Choose a Drug — An Algorithm 321
Amy Z. Crepeau
Epilepsy Journey 9: Treating Status Epilepticus: An Algorithm 325
Sara E. Hocker and Eric T. Payne
Epilepsy Journey 10: Withdrawal of ASDs in Adults: An Algorithm 331
Sarah A. Merrill, Kent R. Richter and Joseph I. Sirven
Epilepsy Journey 11: Withdrawal of ASDs in Seizure-Free Patients Children: The Pediatric
Neurologist’s Perspective 335
Elaine C. Wirrell
Epilepsy Journey 12: Withdrawing ASDs in Adults after Epilepsy Surgery 339
Christian Rosenow, Luca Farrugia, Andrew Pines and Joseph I. Sirven
Epilepsy Journey 13: The Pregnant Patient with Epilepsy: An Algorithm 343
Katherine Noe
Section III Epilepsy: Treatment of Epilepsy: Surgical Management 345
19 Pre-surgical Evaluation 347
David B. Burkholder, Anthony L. Ritaccio and Cheolsu Shin
20 Minimally Invasive Epilepsy Surgery 367
Sanjeet S. Grewal, Robert E. Wharen Jr. and William O. Tatum
21 Intracranial EEG Monitoring 381
Jamie J. Van Gompel, Katherine Noe and Richard S. Zimmerman
22 Surgical Strategies (Include Cortical Resection, Lesionectomy, Cortical Stimulation and Functional Mapping, Hemispherotomy) 401
Angela Bohnen, W. Richard Marsh, Alfredo Quinones-Hinojosa and Kaisorn L. Chaichana
23 Corpus Callosotomy 413
Elaine C. Wirrell, Lily C. Wong-Kisiel and Kai J. Miller
24 Neuromodulation for Epilepsy 431
Brian N. Lundstrom, Robert E. Wharen, Jr and William O. Tatum
25 Emerging Treatments for Epilepsy 441
Gregory A. Worrell, Benjamin H. Brinkmann, Brian N. Lundstrom and Matt Stead
26 Seizure Forecasting in Epilepsy: From Computation to Clinical Practice 451
Benjamin H. Brinkmann, Nicholas M. Gregg and Gregory A. Worrell
Epilepsy Journey 14: The Drug-Resistant Patient: Pre-surgical Evaluation and Surgery-Approach to the “Skip” Candidate 463
Anteneh M. Feyissa and David B. Burkholder
Epilepsy Journey 15: The Drug-Resistant Patient and Discordant Pre-surgical Evaluation 469
Lily C. Wong-Kisiel, Elson L. So and Richard S. Zimmerman
Epilepsy Journey 16: The Drug-Resistant Patient who is not a Candidate for Resective Surgery: An Approach to Neuromodulation 477
Anthony L. Ritaccio and William O. Tatum
Epilepsy Journey 17: Epilepsy Surgery in Pediatric Patients 483
Raj D. Sheth, Kai J. Miller and Elaine C. Wirrell
References 489
Index 491
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