Atlas of Peripheral Blood The Primary Diagnostic Tool PDF

Contributors vii
Preface ix
Acknowledgments xi
1 Introduction 1
Method of Preparing Manual Blood Smears 1
Staining 1
Approach to Interpretation 1
Features of Normal Blood Smears 2
2 Common Red Blood Cell Changes/
Nomenclature 6
Laboratory Red Blood Cell Measurements 6
RBC Shape and Size Changes 8
RBC Inclusions 15
RBC Size 19
3 Anemia Due to Abnormal or
Impaired Hemoglobin Synthesis 22
Defects in Iron Metabolism 22
Defects in Porphyrin Synthesis 23
Defects in Globin Chains Synthesis 25
4 Anemia Due to Abnormal
or Impaired DNA Synthesis 36
Megaloblastic Anemia 36
Myelodysplasia 36
Congenital Dyserythropoietic Anemia 38
Reticulocytosis 38
Liver Disease 40
Alcoholism and Alcoholic Liver Disease 41
5 Hemolytic Anemias 43
Extracorpuscular 43
Intracorpuscular 44
Southeast Asian Ovalocytosis 53
Hereditary Spherocytosis
Hereditary Elliptocytosis Syndromes
Acanthocytosis
6 Reactive Changes in Granulocytes 57
Granulocyte Maturation 57
The Neutrophil 57
7 Systemic Disorders with Granulocyte
and Monocyte Inclusions 67
Introduction 67
Alder-Reilly Anomaly 67
xiii
Morquio Syndrome 67
Hunter Syndrome 69
Hurler Syndrome 70
Chediak-Higashi Syndrome 70
May-Hegglin Anomaly 70
8 Myeloproliferative Neoplasms
and Myeloid and Lymphoid
Neoplasms with Eosinophilia 72
Chronic Myelogenous Leukemia, BCR-ABL1 Positive
(CML) 74
Polycythemia Vera (PV) 78
Primary Myelofibrosis (PMF) 78
Essential Thrombocythemia (ET) 80
Chronic Neutrophilic Leukemia (CNL) 82
Chronic Eosinophilic Leukemia, Not Otherwise
Specified (CEL) 83
Mastocytosis 84
Myeloproliferative Neoplasm, Unclassifiable
(MPN,U) 85
Myeloid and lymphoid neoplasms with
Eosinophilia and Abnormalities of PDGFRA,
PDGFRB, FGFR1
9 Myelodysplastic Syndromes 90
10 Myelodysplastic/Myeloproliferative
Neoplasms 97
Monocyte Maturation 97
Chronic Myelomonocytic Leukemia 97
Atypical Chronic Myeloid Leukemia, BCR-ABL1
Negative 98
Juvenile Myelomonocytic Leukemia 99
Myelodysplastic/Myeloproliferative Neoplasms,
Unclassifiable 101
11 Acute Myeloid Leukemia 103
Ancillary Studies in Acute Myeloid Leukemia 103
Acute Myeloid Leukemia with Recurrent Genetic
Abnormalities 104
Acute Myeloid Leukemia with Myelodysplasia-Related
Changes 110
Therapy-Related Myeloid Neoplasms 112
Acute Myeloid Leukemia, Not Otherwise Specified 114
Myeloid Proliferations Related to Down
Syndrome 121
12 Acute Leukemias of Ambiguous
Lineage 122
Acute Undifferentiated Leukemia 122
Mixed Phenotype Acute Leukemia 123
xiv Contents
17 Mature T- and NK-cell Neoplasms 158
T-Cell Prolymphocytic Leukemia 158
T-Cell Large Granular Lymphocytic Leukemia 160
Sézary Syndrome 161
Adult T-Cell Leukemia/Lymphoma 162
Chronic Lymphoproliferative Disorders of
NK Cells 162
Aggressive NK-Cell Leukemia 164
Other T-Cell Lymphomas 164
Blastic Plasmacytoid Dendritic Cell Neoplasm 166
18 Platelets 168
Pure Platelet Disorders 168
Platelet Abnormalities in Other Disorders 169
19 Blood Changes in Infectious
Disease 173
Protists 173
Malaria
Babesia
Trypanosomes
Bacteria 178
Fungi 180
20 Nonhematopoietic Tumors
in the Blood 185
Index 189
13 Reactive Changes in Lymphocytes 127
Infectious Mononucleosis 128
Other Viral Infections 129
Pertussis 130
Large Granular Lymphocytes 131
14 Precursor Lymphoid Malignancies 132
B-Lymphoblastic Leukemia/Lymphoma with Recurrent
Genetic Abnormalities 135
B-Lymphoblastic Leukemia/Lymphoma, Not
Otherwise Specified 136
T-Lymphoblastic Leukemia/Lymphoma 136
15 Mature Small B-cell Neoplasms
Involving the Blood 139
Chronic Lymphocytic Leukemia 139
B-Prolymphocytic Leukemia 143
Lymphoplasmacytic Lymphoma 144
Multiple Myeloma/Plasma Cell Leukemia 145
Splenic Marginal Zone Lymphoma 147
Extranodal and Nodal Marginal Zone
Lymphomas 148
Hairy Cell Leukemia 149
Hairy Cell Leukemia Variant 150
Follicular Lymphoma 150
Mantle Cell Lymphoma 152
16 Mature Intermediate to Large B-cell
Neoplasms 155
Burkitt Lymphoma/Leukemia 155
Large B-Cell Lymphoma 156
Atlas of Peripheral Blood The Primary Diagnostic Tool PDF Ebook

Irma Pereira, MT (ASCP), SH
Clinical Hematology Specialist
Clinical Laboratories
Stanford University
Stanford, California

Tracy I. George, MD
Assistant Professor of Pathology
Director, Clinical Hematology Laboratory
Stanford University
Stanford, California

Daniel A. Arber, MD
Professor and Vice Chair of Pathology
Medical Director, Anatomic Pathology and Clinical Laboratory Services
Department of Pathology
Stanford University
Stanford, California