Cancer: Principles & Practice of Oncology (Cancer Principles and Practice of Oncology) 10th Edition PDF

P art I
Principles of Oncology
1. The Cancer Genome. 2
Yardena Samuels, Alberto Bardelli, Jared J. Gartner, and
Carlos López-Otin
Introduction 2
Cancer Genes and Their Mutations 2
Identification of Cancer Genes 2
Somatic Alteration Classes Detected by
Cancer Genome Analysis 10
Pathway-Oriented Models of Cancer Genome Analysis 11
Networks of Cancer Genome Projects 13
The Genomic Landscape of Cancers 15
Integrative Analysis of Cancer Genomics 16
The Cancer Genome and the New Taxonomy of Tumors 16
Cancer Genomics and Drug Resistance 19
Perspectives of Cancer Genome Analysis 20
Acknowledgments 20
2. Hallmarks of Cancer: An Organizing
Principle for Cancer Medicine. 24
Douglas Hanahan and Robert A. Weinberg
Introduction 24
Hallmark Capabilities, in Essence 24
Two Ubiquitous Characteristics Facilitate
the Acquisition of Hallmark Capabilities 33
The Constituent Cell Types of the
Tumor Microenvironment 35
Therapeutic Targeting of the Hallmarks of Cancer 41
Conclusion and a Vision for the Future 42
Acknowledgment 43
3. Molecular Methods in Cancer .45
Larissa V. Furtado, Jay L. Hess, and Bryan L. Betz
Applications of Molecular Diagnostics in Oncology 45
The Clinical Molecular Diagnostics Laboratory:
Rules and Regulations 48
Specimen Requirements for Molecular Diagnostics 49
Molecular Diagnostics Testing Process 49
Technologies 50
P art I I
Etiology and Epidemiology
of Cancer
Section 1. Etiology of Cancer
4. Tobacco. 62
Richard J. O’Connor
Introduction 62
Epidemiology of Tobacco and Cancer 62
Carcinogens in Tobacco Products and
Processes of Cancer Development 64
5. Oncogenic Viruses 69
Christopher B. Buck and Lee Ratner
Principles of Tumor Virology 69
Papillomaviruses 71
Polyomaviruses 73
Epstein-Barr Virus 74
Kaposi’s Sarcoma Herpesvirus 75
Animal and Human Retroviruses 77
Hepatitis Viruses 79
Conclusion 81
6. Inflammation.83
Sahdeo Prasad and Bharat B. Aggarwal
Introduction 83
Molecular Basis of Inflammation 83
Role of Inflammation in Transformation 83
Role of Inflammation in Survival 84
Role of Inflammation in Proliferation 85
Role of Inflammation in Invasion 85
Role of Inflammation in Angiogenesis 85
Role of Inflammation in Metastasis 86
Epigenetic Changes and Inflammation 86
Role of Inflammation in Cancer Diagnosis 87
Inflammation and Genomics 87
Inflammation and Targeted Therapies 87
Conclusions 87
7. Chemical Factors .89
Stuart H. Yuspa and Peter G. Shields
Introduction 89
The Nature of Chemical Carcinogens:
Chemistry and Metabolism 89
Animal Model Systems and Chemical Carcinogenesis 90
Molecular Epidemiology, Chemical Carcinogenesis, and
Cancer Risk in Human Populations 91
Aristolochic Acid and Urothelial Cancers as a Model for Identifying
Human Carcinogens 92……
Cancer: Principles & Practice of Oncology (Cancer Principles and Practice of Oncology) 10th Edition PDF Ebook

Vincent T. DeVita, Jr., MD
Amy & Joseph Perella Professor of Medicine
Yale Comprehensive Cancer Center and Smilow
Cancer Hospital at Yale-New Haven
Professor of Epidemiology and Public Health
Yale University School of Public Health
New Haven, Connecticut
Steven A. Rosenberg, MD, PhD
Chief, Surgery Branch, National Cancer Institute, National Institutes of Health
Professor of Surgery, Uniformed Services University of the Health Sciences
School of Medicine
Bethesda, Maryland
Professor of Surgery
George Washington University School of Medicine
Washington, District of Columbia
With 403 Contributing Authors
Theodore S. Lawrence, MD, PhD
Isadore Lampe Professor and Chair
Department of Radiation Oncology
University of Michigan
Ann Arbor, Michigan