Cardiovascular Pathology Fifth Edition PDF

1. Cardiovascular pathology: guide to practice and
training 1
L. MAXIMILIAN BUJA, BIHONG ZHAO, ANA SEGURA,
LAURA LELENWA, MICHELLE MCDONALD AND
KATARZYNA MICHAUD
Introduction 2
Autopsy 2
Genetics and molecular biology 10
Surgical pathology 11
Endomyocardial biopsy 11
Heart transplant pathology 15
Cardiovascular clinical diagnostic and imaging studies 16
Training in cardiovascular pathology 17
Cardiovascular pathologist roles as diagnostician, teacher,
consultant, and care team member 18
Summary 19
References 19
2. Anatomic considerations and examination of
cardiovascular specimens (excluding devices) 27
JOSEPH J. MALESZEWSKI, CHI K. LAI, VIDHYA NAIR AND JOHN P. VEINOT
Gross examination of the heart 28
Examination of surgical cardiovascular specimens 45
Microscopic examination of the blood vessels and heart 49
Genetics 78
Summary 79
References 79
3. Age-related cardiovascular changes and diseases 85
ATSUKO SEKI AND MICHAEL C. FISHBEIN
Introduction 86
Nonspecific cardiovascular changes of aging 86
Changes in the conduction system 94
Changes in arteries 95
Age-related diseases 98
Genetic and molecular aspects of cardiovascular aging 110
Summary 113
References 114
4. Fundamental principles in cardiovascular
genetics 123
MICHAEL A. SEIDMAN AND RICHARD N. MITCHELL
Central concept figure 123
Notable abbreviations 123
Genetic variation 124
Modern molecular diagnostics 127
Identifying the genetic basis of cardiovascular disease 141
Molecular diagnostics in cardiovascular pathology practice 143
Summary 147
References 147
5. Pathophysiology of heart failure and
an overview of therapies 149
M.J. RANEK, J.M. BERTHIAUME, J.A. KIRK, R.C. LYON, F. SHEIKH,
B.C. JENSEN, B.D. HOIT, JAGDISH BUTANY, M. TOLEND,
V. RAO AND M.S. WILLIS
Overview of heart failure 150
Clinical presentation and diagnostic criteria 151
Pathophysiology of heart failure 153
Neurohormonal alterations in heart failure 159
Myocardial architecture 171
Molecular responses and adaptation of cardiac cells 174
Metabolic remodeling in heart failure 177
Short- to intermediate-term circulatory support devices 186
Conclusion 204
Summary 204
References 205
6. Congenital heart disease: pathology,
natural history, and interventions 223
GIULIA OTTAVIANI AND L. MAXIMILIAN BUJA
Abbreviations 223
Introduction 224
Definition 224
Epidemiology 224
Etiology 226
Embryology of the cardiovascular system 229
Clinical features and consequences 235
Specific forms of congenital heart disease 235
Surgical and nonsurgical interventions 254
Congenital heart disease in the adult 256….
Cardiovascular Pathology Fifth Edition PDF Ebook

Professor of Pathology and Laboratory Medicine, Medical School, The University of Texas Health Science Center at Houston (UTHealth); Distinguished Teaching Professor, The University of Texas System; Executive Director, The TMC Library; Editor-in-Chief, Cardiovascular Pathology (the official journal of the Society for Cardiovscular Pathology)

Dr. Buja MD is a Professor of Pathology and Laboratory Medicine at the University of Texas Health Science Center at Houston. His subspecialty interest is cardiovascular pathology with research interests in myocardial cell injury, myocardial ischemia, atherosclerosis and cardiomyopathies.?Dr. Buja teaches medical students, medical residents, clinical fellows, graduate students and research post-doctoral fellows. He also conducts a clinical practice in cardiovascular pathology providing staffing of autopsy cases and surgical pathology consultation of cardiac and vascular cases and interpretation of myocardial biopsies from referrals. He directs a cardiovascular pathology fellowship approved by the Texas Medical Board.?He is the editor-in-chief of Cardiovascular Pathology, the official journal of the Society for Cardiovascular Pathology.?He also serves as the Executive Director of The Texas Medical Center Library located adjacent to the medical school.

Consultant Cardiovascular Pathologist/Director Autopsy Services Co-Editor-in-Chief, Cardiovascular Pathology, Guest Editor, Seminars in Diagnostic Pathology Secretary-Treasurer, WASPaLM, Professor, University of Toronto & Director, Division of Pathology,Dept. of Laboratory Medicine and Pathobiology, University Health Network / Laboratory Medicine Program Toronto General Hospital,Toronto, Ontario, Canada.

Dr. Butany is Professor in the Department of Laboratory Medicine and Pathobiology at the University of Toronto, Canada and Director of the Division of Pathology in the Department. He is a Staff Cardiovascular Pathologist at the University Health Network (Toronto General Hospital Site), and Director of Autopsy Services. His investigative work has primarily been based on clinical investigations and outcomes and collaboration with clinical colleagues in basic and applied research. His major interest has been prosthetic heart valves. Dr. Butany has been involved in teaching at the undergraduate and post-graduate levels, including medical students, pathology residents, cardiology residents and cardiac surgery residents and fellows. He is a founding member of the Society for Cardiovascular Pathology and served as the president from 2007-2009). He has been Co-Editor-in-Chief of Cardiovascular Pathology, the official journal of the Society of Cardiovascular Pathology and continues to serve on its Editorial Board.