Clinical Hematology: Theory & Procedures 6th Edition PDF

About the Author
Preface
PART ONE
Hematology Basics
Safety Practices and Quality in the Hematology Laboratory
An Overview of the Hematology Laboratory
Patient Safety
Safety in the Hematology Laboratory
Safe Work Practices and Protective Techniques for Infection Control
Quality Assessment in the Hematology Laboratory
Quality Control in the Hematology Laboratory
∎ CHAPTER HIGHLIGHTS
∎ REVIEW QUESTIONS
∎ REFERENCES
∎ BIBLIOGRAPHY
Principles of Blood Collection
Quality in Blood Collection
Safe Blood Collection Equipment
Safe Blood Collection Equipment
∎ CHAPTER HIGHLIGHTS
∎ REVIEW QUESTIONS
∎ CASE STUDIES
∎ REFERENCES
∎ BIBLIOGRAPHY
∎ INTERNET SITES
Cellular Morphology and Foundations of Genetic Hematopoietic
Disorders
Cellular Ultrastructure and Organization
Cellular Membranes
Cytoplasmic Organelles and Metabolites
Apoptosis
∎ CHAPTER HIGHLIGHTS
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
PART TWO
Hematopoiesis and Cellular Maturation
Hematopoiesis
Ontogeny of Hematopoiesis
Hematopoietic Organs and Tissues
Secondary Lymphoid Tissues
Cellular Elements of Bone Marrow
Human Stem Cells
Cytokines
Examination of Maturing Blood Cells
Mature Blood Cells in Peripheral Blood
∎ CHAPTER HIGHLIGHTS
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Erythrocytes: Erythropoiesis, Maturation, Membrane Characteristics,
and Metabolic Activities
Erythropoiesis
Disorders Related to Erythrocyte Maturation and Production
Membrane Characteristics and Metabolic Activities of Erythrocytes
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDY
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Erythrocytes: Hemoglobin
Characteristics of Hemoglobin
Hemoglobin Function
Oxygen Dissociation and Alterations
Carbon Dioxide Transport
Biosynthesis of Hemoglobin
Disorders Related to Hemoglobin Biosynthesis
Ontogeny of Hemoglobin
Variant Forms of Normal Hemoglobin
Abnormal Hemoglobin Molecules
Analysis of Hemoglobin
Catabolism of Erythrocytes
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Erythrocytes: Morphology and Inclusions
Erythrocytes: Normal and Abnormal
Types of Variations in Erythrocyte Size
Kinds of Variations in Erythrocyte Shape
Alterations in Erythrocyte Color
Varieties of Erythrocyte Inclusions
Alterations in Erythrocyte Distribution
Parasitic Inclusions in Erythrocytes
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Leukocytes: The Granulocytic and Monocytic Series
Introduction
Granulocytic Series: Production of Neutrophils, Eosinophils, and
Basophils
Granulocyte Sites of Development and Maturation
Distribution of Neutrophils, Eosinophils, and Basophils
Normal Maturational Characteristics of Granulocytes
Leukocyte Surface Markers
The Monocytic-Macrophage Series
Normal Reference Ranges and Variations
Abnormalities in Granulocytic Reference Ranges
Functional Properties of Monocytes/Macrophages
Phagocytosis
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDY
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Leukocytes: Lymphocytes and Plasma Cells
Anatomical Origin and Development of Lymphocytes
Morphological Characteristics of Normal Lymphocytes
Characteristics of Lymphocytes
T Lymphocytes, B Lymphocytes, and Plasma Cell Kinetics
Plasma Cell Development and Maturation
∎ CHAPTER HIGHLIGHTS
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
PART THREE
Hematology Laboratory Assessments
Basic Laboratory Assessment of Erythrocytes, Leukocytes, and
Platelets
The Complete Blood Count
Quantitative Assessment of Erythrocytes
Quantitative Assessment of Leukocytes
Other Leukocyte-Related Assessments
Quantitative Assessment of Platelets
Peripheral Blood Film Evaluation
Semiquantitative Grading of Erythrocyte Morphology
Semiquantitative Assessment of Leukocytes
Semiquantitative Assessment of Platelets
Leukocyte Differential Count
∎ CHAPTER HIGHLIGHTS
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Classification and Laboratory Assessment of Anemias
Overview of Anemia
Development of Anemia
Clinical Signs and Symptoms of Anemia
Classification of Anemias
Laboratory Assessment of Anemias
∎ CHAPTER HIGHLIGHTS
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
PART FOUR
Erythrocyte Disorders
Acute and Chronic Blood Loss Anemia and Anemias Associated with
Systemic Disorders
Acute Blood Loss Anemia
Chronic Blood Loss Anemia
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Bone Marrow Failure Syndromes
Bone Marrow Failure Syndromes
Acquired Aplastic Anemia
Constitutional Bone Marrow Failure Syndromes Associated with
Aplastic Anemia
Bone Marrow Failures Involving a Single-Cell Lineage
Congenital Amegakaryocytic Thrombocytopenia
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Disorders of Iron Metabolism and Heme Synthesis
Iron Deficiency and Iron Overload
Iron Deficiency and Iron Deficiency Anemia
Iron Deficiency Anemia
Anemia of Inflammation or Anemia of Chronic Disorders/Diseases
Disorders Related to Hemoglobin Biosynthesis: Sideroblastic
Anemia
Disorders Related to Hemoglobin Biosynthesis: Hereditary
Hemochromatosis
Disorders Related to Hemoglobin Biosynthesis: Heme (Porphyrin)
Synthesis
Disorders Related to Hemoglobin Biosynthesis: Disorders of
Globulin Synthesis
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Macrocytic and Megaloblastic Anemias
Macrocytic Anemias
Megaloblastic Anemias
Pernicious Anemia
Folic Acid Deficiency Anemia
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDY
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Hemolytic Anemias
Hemolytic Anemias
The Role of Complement in Hemolytic Anemia
Complement-Mediated Disease
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Hemoglobinopathies and Thalassemias
Hemoglobin Defects
Sickle Cell Disease
Sickle Cell Syndromes: Pathogenesis and New Approaches
Thalassemia
Other Hemoglobinopathies
Hereditary Persistence of Fetal Hemoglobin
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
PART FIVE
Nonmalignant Leukocyte Disorders
Disorders of Granulocytes and Monocytes
Granulopoietic Alterations: Quantitative Disorders
Morphological Abnormalities of Mature Granulocytes
Inherited Functional Abnormalities
Granulopoietic Alterations: Qualitative Disorders
Monocyte-Macrophage Disorders
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Disorders of Lymphocytes
Characteristics of Lymphocytes
Lymphocytosis
Disorders Associated with Lymphocytosis
Lymphocytopenia
Immune Disorders Associated with Lymphocytopenia
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
PART SIX
Neoplastic Disorders
Characteristics of Leukemias, Lymphomas, and Myelomas
Comparison of Leukemias, Lymphomas, and Myelomas
Forms of Leukemia
Classifications of Leukemias
Prognosis and Treatment
Factors Related to the Occurrence of Leukemia
Demographic Distribution of Leukemia and Lymphomas
Leukemia Vaccines
∎ CHAPTER HIGHLIGHTS
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Acute Leukemias
General Characteristics of Acute Leukemias
Acute Myeloid Leukemias
Prognosis of AML
Treatment Options
Acute Lymphoblastic Leukemia
Prognosis of ALL
Life-Threatening Emergencies
Future Trends: Vaccines
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Lymphoid and Plasma Cell Neoplasms
Leukemias versus Lymphomas
Chronic Lymphocytosis
T-Cell and NK-Cell Neoplasms
Lymphomas
Hodgkin Disease
Plasma Cell Dyscrasias
Immune Approaches
Waldenström Primary Macroglobulinemia (Lymphoplasmacytic
Lymphoma)
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Myeloproliferative Neoplasms
General Characteristics of Myeloproliferative Neoplasms
Chronic Myelogenous Leukemia
Polycythemia Vera, Essential Thrombocytosis (Essential
Thrombocythemia), and Primary Myelofibrosis
Polycythemia Vera
Primary Myelofibrosis
Essential Thrombocytosis/Essential Thrombocythemia
Mastocytosis
Myeloproliferative Neoplasm, Unclassifiable (MPN-U)
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative
Neoplasms
General Characteristics of Myelodysplastic Syndrome and
Myelodysplastic/Myeloproliferative Neoplasms
Myelodysplastic Syndromes
Relationship of Cytogenetics to Prognosis
Treatment Strategies
Myelodysplastic Syndromes/Myeloproliferative Neoplasms
(MDS/MPN)
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
PART SEVEN
Principles and Disorders of Hemostasis and Thrombosis
Principles of Hemostasis and Thrombosis: Vasculature and Platelets
Overview of Hemostasis and Thrombosis
Blood Vasculature: Structure and Function
Vasculature Physiology
Thrombopoiesis
Cell-Based Mechanism of Hemostasis: Platelet Function
∎ CHAPTER HIGHLIGHTS
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Disorders of Primary Hemostasis and Thrombosis Vasculature and
Platelets
Vascular Abnormalities
Quantitative Platelet Disorders
Qualitative Characteristics of Platelets:
Thrombocytopathy/Thrombocythemia
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDY
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Principles of Hemostasis and Thrombosis: Blood Coagulation
Factors and Natural Coagulant Systems
Blood Coagulation Factors
Normal Protective Mechanisms against Thrombosis
Modern View of Hemostasis
∎ CHAPTER HIGHLIGHTS
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Disorders of Hemostasis and Thrombosis: Blood Coagulation
Factors, Hypercoagulable State, and Anticoagulant Therapy
Introduction
Defective Production
Disorders of Destruction and Consumption
The Hypercoagulable (Thrombophilia)
Anticoagulant Therapy
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
PART EIGHT
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Fundamentals of Hematological Analysis
Body Fluid Analysis
Introduction
Cerebrospinal Fluid
Pleural, Peritoneal, and Pericardial Fluids
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Instrumentation in Hematology
Instrumental Principles
Whole Blood Cell Analysis
Analysis of Instrumental Data Output
Laser Technology
Applications of Flow Cytometry
Digital Microscopy
Instruments in Coagulation Studies
∎ CHAPTER HIGHLIGHTS
∎ CASE STUDIES
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Molecular Diagnostic Techniques and Applications
The Human Genome Project
Molecular Techniques in Hematology
Molecular Genetics in Hematology
Chapter Summary
∎ REVIEW QUESTIONS
∎ BIBLIOGRAPHY
Laboratory Manual: Manual Procedures in Hematology
Procedural Format
∎ REVIEW QUESTIONS
APPENDICES
Answers to Review Questions
Frequently Used Abbreviations
Safety Data Sheets
Tube Guide BD
Tube Guide Greiner
Interleukins
The Microscope
Quick References
Clinical Hematology: Theory & Procedures 6th Edition PDF Ebook

Mary Louise Turgeon, EdD, MLS(ASCP)CM, is an educator, author, and consultant in medical laboratory science education. Her career as an educator includes 15 years as a community college professor and medical laboratory technician (MLT) program director, and 14 years as an undergraduate and graduate university professor, medical laboratory science (MLS) program director, and departmental chairperson. She is an educational consultant at Northeastern University, Boston. Dr. Turgeon is the author of medical laboratory science books (sold in more than 45 countries): Linné & Ringsrud’s Clinical Laboratory Science, 6th ed. (2016) Immunology and Serology in Laboratory Medicine, 5th ed. (2014) Clinical Hematology, 5th ed. (2012) Fundamentals of Immunohematology, 2nd ed. (1995) Clinical Hematology has been translated into Spanish. Immunology and Serology in Laboratory Medicine has been translated into Italian and Chinese. Dr. Turgeon is the author of numerous professional journal articles. Presentation of professional workshops and lectures complement the author’s teaching and writing activities. Her consulting practice, Mary L. Turgeon & Associates focuses on new program development, curriculum revision, and increasing teaching effectiveness through the use of technology.