Endocrine Hypertension: From Basic Science to Clinical Practice First Edition PDF

Endocrine hypertensiondan
overview
Joseph M. Pappachan and
Cornelius J. Fernandez
Introduction 2
Primary hypertension versus secondary
hypertension 2
Individual chapters 3
Catecholamines and blood pressure
regulation 3
Adrenocortical hormones and BP
regulation 3
Hypothalamicepituitaryeadrenal axis and
blood pressure regulation 3
Renin-angiotensinealdosterone system and
blood pressure regulation 4
Monogenic hypertension: an overview 4
Primary aldosteronism (Conn’s syndrome) 4
Familial hyperaldosteronism 5
Congenital adrenal hyperplasia and
hypertension 5
Endocrine hypertension: discovering the
inherited causes 5
Pheochromocytomas and
hypertension 6
Paragangliomas and hypertension 6
ACTH-dependent Cushing syndrome 6
Adrenal Cushing’s syndrome 7
Hypertension in growth hormone excess
(acromegaly) and deficiency 7
Hypertension in thyroid disease and
hyperparathyroidism 7
Obesity, insulin resistance, and obstructive
sleep apnea 7
Endocrine hypertension in children 8
Endocrine hypertension in pregnant
woman 8
Imaging for patients with endocrine
hypertension 8
Systematic approach for the diagnosis and
management of endocrine hypertension 9
Recent trends/emerging concepts 9
Genetic testing for familial PPGL 10
Genetic testing for familial
hyperparathyroidism 10
Genetic testing for familial hyperaldosteronism
especially GRA 11
Conclusions 13
References 14
2. Catecholamines and blood
pressure regulation
Cornelius J. Fernandez, Fahmy W.F. Hanna,
Karel Pacak and Matthew A. Nazari
Introduction 20
Catecholamines and autonomic physiology 20
The synthesis, storage, and regulation of
catecholamines 20
Metabolism of catecholamines 22
Adrenoceptors, subtypes, and associated
second messenger systems 23
Neuroendocrine effects of catecholamines
on blood pressure 25
Metabolic regulation by catecholamines 26
Biologic effects 26
Summarizing the net effect of catecholamines
on vascular hemodynamics 26
PPGLs and excess catecholamine states 28
Deleterious cardiac effects of excess catecholamines:
CICMP 28
Stress cardiomyopathy: impaired adrenoceptor
and second messenger signaling 28
Hypertrophic cardiomyopathy: loaddependent
and nonload-dependent
remodeling 29
Dilated cardiomyopathy: cardiotoxic
effects of catecholamines 29
Deleterious vascular effects of
catecholamines 31…
Endocrine Hypertension: From Basic Science to Clinical Practice First Edition PDF Ebook

Professor Joseph M. Pappachan MD, FRCP is a consultant endocrinologist at Lancashire Teaching Hospitals NHS Trust and an honorary professor at the Manchester Metropolitan University, UK. He is also a section editor (endocrinology & metabolism) to “Current Drug Safety” and associate editor to the “World Journal of Diabetes” and “Frontiers in Clinical Diabetes and Healthcare”. He has vast editing experience including editing journal special issues since 2010 and has authored more than 100 peer-reviewed articles in various medical journals and textbooks. He also has extensive academic collaboration across the globe and is a principal investigator in several ongoing clinical trials in endocrinology & metabolism. His research special interests include endocrine hypertension, neuroendocrinology, parathyroid disease, bone mineral metabolism, diabetic foot disease and diabesity.

Dr. Cornelius James Fernandez MD, MRCP is a consultant endocrinologist at Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston, UK. He graduated from Kottayam Medical College, and underwent internal medicine postgraduate training from Coimbatore Medical College (India) with further specialist training in Endocrinology in the U.K. He is a review editor to “Frontiers in Clinical Diabetes and Healthcare” and scientific peer reviewer to several other medical journals. He has authored 35 peer reviewed scientific papers to date in different medical journals and actively involves in clinical research programs in his hospital. His research special interests include endocrine hypertension, diabetic foot disease and diabesity.