A. THALASSEMIAS, 2
a-Thalassemia, 2
Nicole Pecora and Jeffery L. Kutok
b-Thalassemia, 4
Nicole Pecora and Jeffery L. Kutok
B. HEMOGLOBINOPATHIES, 6
Sickle Cell Disease, 6
Nicole Pecora and Jeffery L. Kutok
Hemoglobin C Disease, 7
Nicole Pecora and Olga Pozdnyakova
Hemoglobin E Disease, 9
Nicole Pecora and Jeffery L. Kutok
Heinz Body Hemolytic Anemia, 10
Diana Mandelker
C. ENZYME DEFECTS, 11
Glucose-6-Phosphate Dehydrogenase
(G6PD) Deficiency, 11
Nicole Pecora and Jeffery L. Kutok
Pyruvate Kinase Deficiency, 12
Diana Mandelker and Olga Pozdnyakova
D. DISORDERS OF HEME SYNTHESIS, 13
Sideroblastic Anemia (Congenital and
Acquired), 13
Nicole Pecora and Jeffery L. Kutok
E. RED CELL MEMBRANE DISORDERS, 14
Hereditary Spherocytosis, 14
Nicole Pecora and Jeffery L. Kutok
Hereditary Elliptocytosis (HE) and Related
Disorders, 15
Nicole Pecora and Jeffery L. Kutok
F. OTHER CONGENITAL RED CELL
DISORDERS, 16
Congenital Dyserythropoietic Anemia (CDA), 16
Nicole Pecora and Jeffery L. Kutok
II. ACQUIRED RED CELL DISORDERS, 17
A. RED CELL MEMBRANE DISORDERS, 18
Paroxysmal Nocturnal Hemoglobinuria (PNH), 18
Nicole Pecora and Olga Pozdnyakova
B. NUTRITIONAL DEFICIENCIES, 19
Iron Deficiency Anemia (IDA), 19
Nicole Pecora and Jeffery L. Kutok
Folate and B12 (Cobalamin) Deficiency, 20
Michael G. Drage and Jeffery L. Kutok
C. TOXINS, 22
Lead Toxicity, 22
Michael G. Drage and Jeffery L. Kutok
Hematologic Complications of Alcoholism, 23
Michael G. Drage and Jon C. Aster
D. INTRAVASCULAR HEMOLYSIS, 24
Traumatic Hemolysis, 24
Diana Mandelker
E. IMMUNOLOGIC DESTRUCTION, 25
Autoimmune Hemolytic Anemia (AIHA), 25
Olga Pozdnyakova and Jeffery L. Kutok
F. MYELOPHTHISIC ANEMIAS, 26
Metastatic Lesions in Bone Marrow Biopsies, 26
Benjamin J. Chen
Gaucher Disease, 29
Elizabeth A. Morgan
Storage Disorders: Niemann-Pick Disease
(NPD), 30
Olga Pozdnyakova
G. RED CELL APLASIAS, 31
Red Cell Aplasia, 31
Elizabeth A. Morgan
Parvovirus Infection, 33
Elizabeth A. Morgan
III. INHERITED WHITE CELL AND
PLATELET DISORDERS, 35
Chédiak-Higashi Syndrome, 36
Diana Mandelker
Gray Platelet Syndrome, 37
Olga Pozdnyakova
May-Hegglin Anomaly, 39
Diana Mandelker
Pelger-Huët Anomaly, 40
Diana Mandelker and Olga Pozdnyakova
IV. INFECTIOUS DISORDERS SEEN IN
BLOOD, 41
Malaria, 42
Elizabeth A. Morgan
Babesiosis, 44
Elizabeth A. Morgan
Ehrlichiosis/Anaplasmosis, 45
Olga Pozdnyakova
African Trypanosomiasis, 46
Olga Pozdnyakova
Chagas Disease, 47
Olga Pozdnyakova
V. DISORDERS OF HEMOSTASIS, 49
Disseminated Intravascular Coagulation (DIC), 50
Elizabeth A. Morgan
Thrombotic Thrombocytopenia Purpura (TTP)/
Hemolytic Uremic Syndrome (HUS), 51
Elizabeth A. Morgan….
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