Lanzkowsky’s Manual of Pediatric Hematology and Oncology Seventh Edition PDF

clinicians 1
JORDAN A. SHAVIT AND RAJEN J. MODY
Clinical molecular and genomic methodologies: goals 1
Methods of genetic analysis 1
Interpretation of genetic variants obtained from next-generation
sequencing 4
Applications of next-generation sequencing to oncology 4
Interpreting and evaluating the results from clinical genetic
testing 6
Further reading and references 6
2. Hematologic manifestations of systemic illness 7
BRIAN M. DULMOVITS AND LAWRENCE C. WOLFE
Alterations to red blood cells related to organ-specific
pathologies 7
Alterations to white blood cells related to organ-specific
pathologies 12
Alterations to platelets and coagulation related to
organ-specific pathologies 13
General considerations for the hematologic sequelae of
infection 15
Viral and bacterial illnesses associated with marked
hematologic sequelae 15
Parasitic illnesses associated with marked hematologic
sequelae 21
Hemolytic uremic syndrome 22
Autoimmune disease 23
Anemia of inflammation 25
Nutritional deficiencies and environmental exposures 27
Marrow infiltrative disorders 28
Further reading and references 34
3. Classification and diagnosis of anemia in
children and neonates 37
OMAR NISS AND CHARLES T. QUINN
Classification and diagnosis 37
Neonatal anemia 40
Further reading and references 59
4. Nutritional anemias 61
JACQUELYN M. POWERS
Overview 61
Iron-deficiency anemia 61
Megaloblastic anemia 71
Further reading and references 80
5. Lymphadenopathy and diseases of the spleen 81
PHILIP LANZKOWSKY
Lymphadenopathy 81
Diseases of the spleen 86
Further reading and references 89
6. Bone marrow failure 91
ADRIANNAVLACHOS, MICHELLE NASH AND JEFFREY M. LIPTON
Aplastic anemia 91
Inherited bone marrow failure syndromes 102
Further reading and references 122
7. General considerations of hemolytic diseases,
red cell membrane, and enzyme defects 125
LIONEL BLANC AND LAWRENCE C. WOLFE
Clinical features of hemolytic disease 125
Laboratory findings 126
Membrane defects 128
Paroxysmal nocturnal hemoglobinuria 138
Enzyme defects 142
Further reading and references 148
8. Extracorpuscular hemolytic anemia 151
ANSHULVAGRECHA AND LAWRENCE C. WOLFE
Immune hemolytic anemia 151
Nonimmune hemolytic anemia 158
Further reading and references 159
Lanzkowsky’s Manual of Pediatric Hematology and Oncology Seventh Edition PDF Ebook
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JEFFREY M. LIPTON, MD, PHD
Chief, Division of Pediatric Hematology-Oncology and Stem Cell Transplantation
Cohen Children’s Medical Center of New York, Northwell Health, New Hyde Park, New York
Frances and Thomas Gambino Professor of Hematology-Oncology
Professor of Pediatrics and Molecular Medicine
Professor, Institute of Molecular Medicine, Feinstein Institutes for Medical Research
Zucker School of Medicine at Hofstra Northwell, Hempstead, New York

PHILIP LANZKOWSKY, MBCHB, MD, SCD (HONORIS CAUSA), FRCP, DCH, FAAP
Chief Emeritus, Division of Pediatric Hematology-Oncology and Stem Cell Transplantation
Chairman Emeritus, Department of Pediatrics
Executive Director and Chief-of-Staff (Retired)
Cohen Children’s Medical Center of New York, Northwell Health, New Hyde Park, New York
Vice President, Children’s Health Network (Retired),
Professor of Pediatrics
Zucker School of Medicine at Hofstra Northwell, Hempstead, New York