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Red Cell Shape: Physiology, Pathology, Ultrastructure First Edition PDF

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Red Cell Shape: Physiology, Pathology, Ultrastructure First Edition PDF
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This monograph is a collection of invited contributions from a group of investiga­ tors who share a common interest in the interrelationships between the shape, struc­ ture, and functional characteristics of normal and pathologic erythrocytes. Most of the authors participated in a workshop on red cell shape held in June, 1972 at the Institute of Cell Pathology, Hopital de Bicetre, Paris. We hope that these various contributions on the physiology, pathology, and ultrastructure of red cell shape will be useful and stimulating for other investigators interested in the correlation of shape and structure with the biochemistry and biophysics of the red cell. The text is divided into four sections. Section I deals with red cell shape, including the presentation of a rational descriptive nomenclature and a discussion of post­ splenectomy changes. Section II deals with biochemical factors that underlie the disco­ cyte-echinocyte (crenated) and discocyte-stomatocyte (cup-shaped) transformation. This section includes discussions of plasma factors, and of the biochemical dynamics of erythrocyte lipids and consideration of the effects of such factors as cellular ATP, calcium, aging, and various chemical agents as determinants of shape. Section III, which deals with biophysical measurements, includes studies of the deformability of cells of different shapes, descriptions of ways to define precisely the geometric dimensions of the red cell under various circumstances, and a model of membrane structure, which is proposed to account for the dimensions of red cells that undergo shape change.

E-Book Details
Сategories: Biology-Genetics
Language ‏ : ‎ English
Print length ‏ : ‎ 320 pages
Table of Contents
Section I. – Red Cell Shape and Nomenclature
M. BESSIS. – Red Cell Shapes: An Illustrated Classification and Its Rationale 1
G. BRECHER. – Nomenclature of Red Cell Shapes. A Commentary•. 27
G. BRECHER, J. E. HALEY and R. O. WALLERSTEIN. – Spiculed Erythrocytes after Splenectomy
Acanthocytes or Non-specific Poikilocytes?.• 31
Section II. – Discocyte-Echinocyte and Discocyte-Stomatocyte Transformations
M. A. LICHTMAN and G. V. MARINETTI. – Erythrocyte Shape Alteration “in vitro”: Relationship
to Plasma and Cellular Factors. Abstract ••.•.•.• 35
C. FEO. – The Role of Lysolecithin Formed in Plasma on the Discocyte-echinocyte Transformation.
A Commentary.• 37
S. B. SHOHET and J. E. HALEY. – Red Cell Membrane Shape and Stability: Relation to Cell
Lipid Renewal Pathways and Cell ATP 41
J. F. HOFFMAN. – Quantitative Study of Factors which Control Shape Transformations of
Human Red Blood Cells of Constant Volume••.••.••.• 51
R. I. WEED and B. CHAILLEY. – Calcium-pH Interactions in the Production of Shape Change
in Erythrocytes.••.•• 55
P. L. LA CELLE, F. H. KIRKPATRICK, M. P. UDKOW and B. ARKIN. – Membrane Fragmentation
and Ca++-membrane Interaction: Potential Mechanisms of Shape Change in the Senescent
Red Cell•••••. 69
M. A. LICHTMAN and R. I. WEED. – Divalent Cation Content of Normal and ATP-depleted
Erythrocytes and Erythrocyte Membranes•. 79
Section III. – Biophysical Studies and Membrane Models
P. F. LEBLOND. – The Discocyte-echinocyte Transformation of the Human Red Cell: Deformability
Characteristics 95
P. B. CANHAM. – Hemolysis, Induced by PUlsed Laser Irradiation, Transmitted along
Rouleaux of Human Red Blood Cells•. 105
B. BULL. – Red Cell Biconcavity and Deformability. A Macromodel Based on Flow Chamber
Observations.• 115
B. BULL. – A Simple Flow Chamber for Hydraulic Manipulation of Individual Cells 125
E. A. EVANS and P. F. LEBLOND. – Image Holograms of Red Single Blood Cell Discocytespheroechinocyte
Transformations.• 131
M. EDEN. – Image Processing Teclmiques in Relation to Studies of Red Cell Shape 141
Section IV. – Membrane Ultrastructure: Freeze-Cleave and Freeze-Etch Studies
L. S. LESSIN. – Membrane Ultrastructure of Normal, Sickled and Heinz-body Erythrocytes
by Freeze-etching•.•.•. 151
P. SEEMAN and G. H. ILES. – Pits in the Freeze-cleavage Plane of Normal Erythrocyte Membranes
and Ultrastructure of Membrane Lesions in Immune Lysis 169…
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About the Authors
Marcel Bessis
Robert I~W eed
Pierre F. Leblond
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