Textbook of Pulmonary and Critical Care Medicine First Edition PDF

1. History of Respiratory Medicine 3
FE Udwadia
Introduction 3; The Discovery of Chemotherapy and Antibiotics 6
2. Anatomy and Architecture: A Clinical Perspective 9
SK Jindal
Lung Anatomy and Morphology 9; Architecture of Lung Parenchyma 12; Blood Supply of
Lungs 13; Lymphatic Drainage 14; Nerve Supply 15
3. Lung Development 18
Meenu Singh, Nidhi Anil, Amit Agarwal
Introduction 18
4. Genomics of Lung Diseases 24
L Keith Scott
Introduction 24; Genomics and Disease 24; Genomic Nomenclature and Investigational
Tools 25
SECTION 2: RESPIRATORY PHYSIOLOGY
SK Chhabra
5. Applied Respiratory Physics 35
SK Jindal, VK Jindal
Introduction 35; State of Matter 35; Physical Properties of Gases 36; The Gas Laws 38;
Gas Solution and Tension 39; Vapors 39; Expression of Gas Volumes and Pressures 40;
Flow of Gases 40
6. Respiratory Function and Mechanics 43
D Gupta, R Agarwal, Ashutosh N Aggarwal
Introduction 43; Ventilation 44; Pulmonary Circulation 48; Diffusion 50; Ventilation-perfusion
(V./Q. ) Relationships 51; Control of Ventilation 52
7. Gas and Fluid Exchange in the Lung 54
Marc Zelter
Gas Exchange 54; Dead Space and Alveolar Gas 56; Transfer of Gas across the Alveolar Capillary
Membrane 57; Gas Transport to and from the Periphery 58; Ventilation Perfusion Ratio 60;
Fluid, Solutes and Protein Exchange in the Lung 64; Clinical Implications 71; Measurement of
Extravascular Lung Water 72
8. Tissue Oxygenation 74
Puneet Malhotra, SK Jindal
Introduction 74; Oxygen Delivery (DO2) 74; Oxygen Consumption (VO2) 76; Assessment of
Tissue Oxygenation 78; Recent Developments 79
9. Respiratory Physiology in Specific Physiological States 81
Sunil K Chhabra, Mansi Gupta
Introduction 81; Exercise 81; Pregnancy 84; High Altitude 86; Deep Diving 88
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TEXTBOOK OF PULMONARY AND CRITICAL CARE MEDICINE
10. Mechanisms of Dyspnea in Respiratory Diseases 93
Sunil K Chhabra, Ashima Anand
Introduction 93; Definitions 93; Perception: The Subjective Element in Dyspnea 94; Neural
Pathways of Dyspnea 94; Pathophysiological Mechanisms of Dyspnea 97
11. Surfactant 107
Gyanendra Agrawal, SK Jindal
Introduction 107; Composition of Lung Surfactant 107; Functions of Lung Surfactant 109;
Surfactant Metabolism and Surfactant Film Formation 110; Disorders of Surfactant
Metabolism 112; Conclusion 115
12. Respiratory Defenses and Immunology 118
Padmavathi Ramaswamy, Padma Srikanth, Vijayalakshmi Thanasekaraan
Introduction 118; Particle Deposition in the Respiratory Tract 119; The Defense Mechanisms of
Conducting Zone of the Airways 119; The Defense Mechanisms of Respiratory Zone of the
Airways 124; Surfactant and Surfactant Protein A (Sp-A) 125; Respiratory Immune Mechanisms
126; Alveolar Macrophages 127; Impact of Bacteria and Viruses on Lung Immunology 130;
HLA and Mycobacterial Diseases 131
SECTION 3: PHARMACOLOGICAL AGENTS
Nusrat Shafiq, Samir Malhotra
13. Antibacterial Drugs 135
Nusrat Shafiq, Samir Malhotra
Introduction 135; Beta-lactams 135
14. Antiviral Drugs 155
Nusrat Shafiq, Samir Malhotra
Introduction 155; Mechanism of Action of Antiviral Drugs 156
15. Antifungal Drugs 159
J Whig, Bharti Mahajan, Rajesh Mahajan
Introduction 159; Specific Issues 166; Clinical Implications of the Antifungal Drugs 166
16. Anti-inflammatory Agents for Asthma 171
Nusrat Shafiq, Samir Malhotra
Introduction 171; Corticosteroids 171; Dissociated Steroids 173; Mast Cell Stabilizers 176;
Miscellaneous Drugs 177
17. Immunosuppressant Drugs 180
Nusrat Shafiq, Samir Malhotra
Introduction 180; Glucocorticoids 180; Calcineurin Inhibitors 181; Antiproliferative/
Antimetabolic Drugs 182; Immunosuppressive Cytotoxic Drugs 183; Miscellaneous
Immunosuppressants 184
SECTION 4: SYMPTOM-APPROACH TO RESPIRATORY DISEASE
Richard S Irwin
18. Cough in the Adult 189
Scott E Kopec, Deirdre L Kathman, Richard S Irwin
Introduction 189; Epidemiology 189; Physiology 189; Pathophysiology 190; Benefits of
Cough 190; Complications of Cough 190; Causes of Cough 191
19. Hemoptysis 204
Andrés F Sosa, J Mark Madison, Paulo J Oliveira
Introduction 204; Anatomy 205; Etiology and Pathogenesis 205; Treatment 213…
Textbook of Pulmonary and Critical Care Medicine First Edition PDF Ebook

SK Jindal MD FNCCP FAMS FCCP
Professor and Head
Department of Pulmonary Medicine
Professor-in-Charge
Telemedicine
Postgraduate Institute of Medical Education and Research
Chandigarh, India